Yizhe Zhang, Shuo Wang, Tao Zhou, Qi Dou, Danny Z. Chen
Segmentation quality assessment (SQA) plays a critical role in the deployment of a medical image based AI system. Users need to be informed/alerted whenever an AI system generates unreliable/incorrect predictions. With the introduction of the Segment Anything Model (SAM), a general foundation segmentation model, new research opportunities emerged in how one can utilize SAM for medical image segmentation. In this paper, we propose a novel SQA method, called SQA-SAM, which exploits SAM to enhance the accuracy of quality assessment for medical image segmentation. When a medical image segmentation model (MedSeg) produces predictions for a test image, we generate visual prompts based on the predictions, and SAM is utilized to generate segmentation maps corresponding to the visual prompts. How well MedSeg's segmentation aligns with SAM's segmentation indicates how well MedSeg's segmentation aligns with the general perception of objectness and image region partition. We develop a score measure for such alignment. In experiments, we find that the generated scores exhibit moderate to strong positive correlation (in Pearson correlation and Spearman correlation) with Dice coefficient scores reflecting the true segmentation quality.
Yizhe Zhang, Shuo Wang, Yejia Zhang, Danny Z. Chen
Conformal prediction (CP) generates a set of predictions for a given test sample such that the prediction set almost always contains the true label (e.g., 99.5\% of the time). CP provides comprehensive predictions on possible labels of a given test sample, and the size of the set indicates how certain the predictions are (e.g., a set larger than one is `uncertain'). Such distinct properties of CP enable effective collaborations between human experts and medical AI models, allowing efficient intervention and quality check in clinical decision-making. In this paper, we propose a new method called Reliable-Region-Based Conformal Prediction (RR-CP), which aims to impose a stronger statistical guarantee so that the user-specified error rate (e.g., 0.5\%) can be achieved in the test time, and under this constraint, the size of the prediction set is optimized (to be small). We consider a small prediction set size an important measure only when the user-specified error rate is achieved. Experiments on five public datasets show that our RR-CP performs well: with a reasonably small-sized prediction set, it achieves the user-specified error rate (e.g., 0.5\%) significantly more frequently than exiting CP methods.
Yizhe Zhang, Lin Yang, Hao Zheng, Peixian Liang, Colleen Mangold, Raquel G. Loreto, David P. Hughes, Danny Z. Chen
Supervised training a deep neural network aims to "teach" the network to mimic human visual perception that is represented by image-and-label pairs in the training data. Superpixelized (SP) images are visually perceivable to humans, but a conventionally trained deep learning model often performs poorly when working on SP images. To better mimic human visual perception, we think it is desirable for the deep learning model to be able to perceive not only raw images but also SP images. In this paper, we propose a new superpixel-based data augmentation (SPDA) method for training deep learning models for biomedical image segmentation. Our method applies a superpixel generation scheme to all the original training images to generate superpixelized images. The SP images thus obtained are then jointly used with the original training images to train a deep learning model. Our experiments of SPDA on four biomedical image datasets show that SPDA is effective and can consistently improve the performance of state-of-the-art fully convolutional networks for biomedical image segmentation in 2D and 3D images. Additional studies also demonstrate that SPDA can practically reduce the generalization gap.
Yizhe Zhang, Xiangyu Wang, Changyou Chen, Ricardo Henao, Kai Fan, Lawrence Carin
We unify slice sampling and Hamiltonian Monte Carlo (HMC) sampling, demonstrating their connection via the Hamiltonian-Jacobi equation from Hamiltonian mechanics. This insight enables extension of HMC and slice sampling to a broader family of samplers, called Monomial Gamma Samplers (MGS). We provide a theoretical analysis of the mixing performance of such samplers, proving that in the limit of a single parameter, the MGS draws decorrelated samples from the desired target distribution. We further show that as this parameter tends toward this limit, performance gains are achieved at a cost of increasing numerical difficulty and some practical convergence issues. Our theoretical results are validated with synthetic data and real-world applications.
Yizhe Zhang, Qiang Chen, Tao Zhou
The emergence of powerful, general-purpose omnimodels capable of processing diverse data modalities has raised a critical question: can these ``jack-of-all-trades'' systems perform on par with highly specialized models in knowledge-intensive domains? This work investigates this question within the high-stakes field of medical image segmentation. We conduct a comparative study analyzing the zero-shot performance of a state-of-the-art omnimodel (Gemini, the ``Nano Banana'' model) against domain-specific deep learning models on three distinct tasks: polyp (endoscopy), retinal vessel (fundus), and breast tumor segmentation (ultrasound). Our study focuses on performance at the extremes by curating subsets of the ``easiest'' and ``hardest'' cases based on the specialist models' accuracy. Our findings reveal a nuanced and task-dependent landscape. For polyp and breast tumor segmentation, specialist models excel on easy samples, but the omnimodel demonstrates greater robustness on hard samples where specialists fail catastrophically. Conversely, for the fine-grained task of retinal vessel segmentation, the specialist model maintains superior performance across both easy and hard cases. Intriguingly, qualitative analysis suggests omnimodels may possess higher sensitivity, identifying subtle anatomical features missed by human annotators. Our results indicate that while current omnimodels are not yet a universal replacement for specialists, their unique strengths suggest a potential complementary role with specialist models, particularly in enhancing robustness on challenging edge cases.
Tianyu Huang, Tao Zhou, Weidi Xie, Shuo Wang, Qi Dou, Yizhe Zhang
The current variants of the Segment Anything Model (SAM), which include the original SAM and Medical SAM, still lack the capability to produce sufficiently accurate segmentation for medical images. In medical imaging contexts, it is not uncommon for human experts to rectify segmentations of specific test samples after SAM generates its segmentation predictions. These rectifications typically entail manual or semi-manual corrections employing state-of-the-art annotation tools. Motivated by this process, we introduce a novel approach that leverages the advantages of online machine learning to enhance Segment Anything (SA) during test time. We employ rectified annotations to perform online learning, with the aim of improving the segmentation quality of SA on medical images. To improve the effectiveness and efficiency of online learning when integrated with large-scale vision models like SAM, we propose a new method called Auxiliary Online Learning (AuxOL). AuxOL creates and applies a small auxiliary model (specialist) in conjunction with SAM (generalist), entails adaptive online-batch and adaptive segmentation fusion. Experiments conducted on eight datasets covering four medical imaging modalities validate the effectiveness of the proposed method. Our work proposes and validates a new, practical, and effective approach for enhancing SA on downstream segmentation tasks (e.g., medical image segmentation).
Georgia Gabriela Sampaio, Ruixiang Zhang, Shuangfei Zhai, Jiatao Gu, Josh Susskind, Navdeep Jaitly, Yizhe Zhang
Evaluating text-to-image generative models remains a challenge, despite the remarkable progress being made in their overall performances. While existing metrics like CLIPScore work for coarse evaluations, they lack the sensitivity to distinguish finer differences as model performance rapidly improves. In this work, we focus on the text rendering aspect of these models, which provides a lens for evaluating a generative model's fine-grained instruction-following capabilities. To this end, we introduce a new evaluation framework called TypeScore to sensitively assess a model's ability to generate images with high-fidelity embedded text by following precise instructions. We argue that this text generation capability serves as a proxy for general instruction-following ability in image synthesis. TypeScore uses an additional image description model and leverages an ensemble dissimilarity measure between the original and extracted text to evaluate the fidelity of the rendered text. Our proposed metric demonstrates greater resolution than CLIPScore to differentiate popular image generation models across a range of instructions with diverse text styles. Our study also evaluates how well these vision-language models (VLMs) adhere to stylistic instructions, disentangling style evaluation from embedded-text fidelity. Through human evaluation studies, we quantitatively meta-evaluate the effectiveness of the metric. Comprehensive analysis is conducted to explore factors such as text length, captioning models, and current progress towards human parity on this task. The framework provides insights into remaining gaps in instruction-following for image generation with embedded text.
Yizhe Zhang
Manual annotation of medical images is a labor-intensive and time-consuming process, posing a significant bottleneck in the development and deployment of robust medical imaging AI systems. This paper introduces a novel hands-free Human-AI collaborative framework for medical image segmentation that substantially reduces the annotation burden by eliminating the need for explicit manual pixel-level labeling. The core innovation lies in a preference learning paradigm, where human experts provide minimal, intuitive feedback -- simply indicating whether an AI-generated segmentation is better or worse than a previous version. The framework comprises four key components: (1) an adaptable foundation model (FM) for feature extraction, (2) label propagation based on feature similarity, (3) a clicking agent that learns from human better-or-worse feedback to decide where to click and with which label, and (4) a multi-round segmentation learning procedure that trains a state-of-the-art segmentation network using pseudo-labels generated by the clicking agent and FM-based label propagation. Experiments on three public datasets demonstrate that the proposed approach achieves competitive segmentation performance using only binary preference feedback, without requiring experts to directly manually annotate the images.
Yizhe Zhang, Deng Cai
Efficient transformer variants with linear time complexity have been developed to mitigate the quadratic computational overhead of the vanilla transformer. Among them are low-rank projection methods such as Linformer and kernel-based Transformers. Despite their unique merits, they usually suffer from a performance drop comparing with the vanilla transformer on many sequence generation tasks, and often fail to obtain computation gain when the generation is short. We propose MemSizer, an approach towards closing the performance gap while improving the efficiency even with short generation. It projects the source sequences into lower dimension representations like Linformer, while enjoying efficient recurrent-style incremental computation similar to kernel-based transformers. This yields linear computation time and constant memory complexity at inference time. MemSizer also employs a lightweight multi-head mechanism which renders the computation as light as a single-head model. We demonstrate that MemSizer provides an improved balance between efficiency and accuracy over the vanilla transformer and other efficient transformer variants in three typical sequence generation tasks, including machine translation, abstractive text summarization, and language modeling.
Yizhe Zhang, Michel Galley, Jianfeng Gao, Zhe Gan, Xiujun Li, Chris Brockett, Bill Dolan
Responses generated by neural conversational models tend to lack informativeness and diversity. We present Adversarial Information Maximization (AIM), an adversarial learning strategy that addresses these two related but distinct problems. To foster response diversity, we leverage adversarial training that allows distributional matching of synthetic and real responses. To improve informativeness, our framework explicitly optimizes a variational lower bound on pairwise mutual information between query and response. Empirical results from automatic and human evaluations demonstrate that our methods significantly boost informativeness and diversity.
Yizhe Zhang, Siqi Sun, Michel Galley, Yen-Chun Chen, Chris Brockett, Xiang Gao, Jianfeng Gao, Jingjing Liu, Bill Dolan
We present a large, tunable neural conversational response generation model, DialoGPT (dialogue generative pre-trained transformer). Trained on 147M conversation-like exchanges extracted from Reddit comment chains over a period spanning from 2005 through 2017, DialoGPT extends the Hugging Face PyTorch transformer to attain a performance close to human both in terms of automatic and human evaluation in single-turn dialogue settings. We show that conversational systems that leverage DialoGPT generate more relevant, contentful and context-consistent responses than strong baseline systems. The pre-trained model and training pipeline are publicly released to facilitate research into neural response generation and the development of more intelligent open-domain dialogue systems.
Yizhe Zhang, Shubhankar Borse, Hong Cai, Ying Wang, Ning Bi, Xiaoyun Jiang, Fatih Porikli
In this paper, we present a novel perceptual consistency perspective on video semantic segmentation, which can capture both temporal consistency and pixel-wise correctness. Given two nearby video frames, perceptual consistency measures how much the segmentation decisions agree with the pixel correspondences obtained via matching general perceptual features. More specifically, for each pixel in one frame, we find the most perceptually correlated pixel in the other frame. Our intuition is that such a pair of pixels are highly likely to belong to the same class. Next, we assess how much the segmentation agrees with such perceptual correspondences, based on which we derive the perceptual consistency of the segmentation maps across these two frames. Utilizing perceptual consistency, we can evaluate the temporal consistency of video segmentation by measuring the perceptual consistency over consecutive pairs of segmentation maps in a video. Furthermore, given a sparsely labeled test video, perceptual consistency can be utilized to aid with predicting the pixel-wise correctness of the segmentation on an unlabeled frame. More specifically, by measuring the perceptual consistency between the predicted segmentation and the available ground truth on a nearby frame and combining it with the segmentation confidence, we can accurately assess the classification correctness on each pixel. Our experiments show that the proposed perceptual consistency can more accurately evaluate the temporal consistency of video segmentation as compared to flow-based measures. Furthermore, it can help more confidently predict segmentation accuracy on unlabeled test frames, as compared to using classification confidence alone. Finally, our proposed measure can be used as a regularizer during the training of segmentation models, which leads to more temporally consistent video segmentation while maintaining accuracy.
Yizhe Zhang, Siqi Sun, Xiang Gao, Yuwei Fang, Chris Brockett, Michel Galley, Jianfeng Gao, Bill Dolan
Recent advances in large-scale pre-training such as GPT-3 allow seemingly high quality text to be generated from a given prompt. However, such generation systems often suffer from problems of hallucinated facts, and are not inherently designed to incorporate useful external information. Grounded generation models appear to offer remedies, but their training typically relies on rarely-available parallel data where information-relevant documents are provided for context. We propose a framework that alleviates this data constraint by jointly training a grounded generator and document retriever on the language model signal. The model learns to reward retrieval of the documents with the highest utility in generation, and attentively combines them using a Mixture-of-Experts (MoE) ensemble to generate follow-on text. We demonstrate that both generator and retriever can take advantage of this joint training and work synergistically to produce more informative and relevant text in both prose and dialogue generation.
Yizhe Zhang, Changyou Chen, Zhe Gan, Ricardo Henao, Lawrence Carin
Recent advances in stochastic gradient techniques have made it possible to estimate posterior distributions from large datasets via Markov Chain Monte Carlo (MCMC). However, when the target posterior is multimodal, mixing performance is often poor. This results in inadequate exploration of the posterior distribution. A framework is proposed to improve the sampling efficiency of stochastic gradient MCMC, based on Hamiltonian Monte Carlo. A generalized kinetic function is leveraged, delivering superior stationary mixing, especially for multimodal distributions. Techniques are also discussed to overcome the practical issues introduced by this generalization. It is shown that the proposed approach is better at exploring complex multimodal posterior distributions, as demonstrated on multiple applications and in comparison with other stochastic gradient MCMC methods.
Yizhe Zhang, Yucheng Jin, Li Chen, Ting Yang
Conversational recommender systems (CRS) enable users to articulate their preferences and provide feedback through natural language. With the advent of large language models (LLMs), the potential to enhance user engagement with CRS and augment the recommendation process with LLM-generated content has received increasing attention. However, the efficacy of LLM-powered CRS is contingent upon the use of prompts, and the subjective perception of recommendation quality can differ across various recommendation domains. Therefore, we have developed a ChatGPT-based CRS to investigate the impact of these two factors, prompt guidance (PG) and recommendation domain (RD), on the overall user experience of the system. We conducted an online empirical study (N = 100) by employing a mixed-method approach that utilized a between-subjects design for the variable of PG (with vs. without) and a within-subjects design for RD (book recommendations vs. job recommendations). The findings reveal that PG can substantially enhance the system's explainability, adaptability, perceived ease of use, and transparency. Moreover, users are inclined to perceive a greater sense of novelty and demonstrate a higher propensity to engage with and try recommended items in the context of book recommendations as opposed to job recommendations. Furthermore, the influence of PG on certain user experience metrics and interactive behaviors appears to be modulated by the recommendation domain, as evidenced by the interaction effects between the two examined factors. This work contributes to the user-centered evaluation of ChatGPT-based CRS by investigating two prominent factors and offers practical design guidance.
Yizhe Zhang, Navdeep Jaitly
Recent advances in large language models have demonstrated impressive capabilities in task-oriented applications, yet building emotionally intelligent chatbots that can engage in natural, strategic conversations remains a challenge. We present a novel approach called SAGE that uses latent variables to control long-horizon behavior in dialogue generation. At the core of our method is the State-Action Chain (SAC), which augments standard language model fine-tuning by introducing latent variables that encapsulate emotional states and conversational strategies between dialogue turns. During inference, these variables are generated before each response, enabling coarse-grained control over dialogue progression while maintaining natural interaction patterns. We also introduce a self-improvement pipeline that leverages dialogue tree search, LLM-based reward modeling, and targeted fine-tuning to optimize conversational trajectories. Our experimental results show that models trained with this approach demonstrate improved performance in emotional intelligence metrics while maintaining strong capabilities on LLM benchmarks. The discrete nature of our latent variables facilitates search-based strategies and provides a foundation for future applications of reinforcement learning to dialogue systems, where learning can occur at the state level rather than the token level. https://github.com/apple/ml-sage-dialog-gen
Liqun Chen, Shuyang Dai, Chenyang Tao, Dinghan Shen, Zhe Gan, Haichao Zhang, Yizhe Zhang, Lawrence Carin
Generative adversarial networks (GANs) have achieved significant success in generating real-valued data. However, the discrete nature of text hinders the application of GAN to text-generation tasks. Instead of using the standard GAN objective, we propose to improve text-generation GAN via a novel approach inspired by optimal transport. Specifically, we consider matching the latent feature distributions of real and synthetic sentences using a novel metric, termed the feature-mover's distance (FMD). This formulation leads to a highly discriminative critic and easy-to-optimize objective, overcoming the mode-collapsing and brittle-training problems in existing methods. Extensive experiments are conducted on a variety of tasks to evaluate the proposed model empirically, including unconditional text generation, style transfer from non-parallel text, and unsupervised cipher cracking. The proposed model yields superior performance, demonstrating wide applicability and effectiveness.
Yunchen Pu, Shuyang Dai, Zhe Gan, Weiyao Wang, Guoyin Wang, Yizhe Zhang, Ricardo Henao, Lawrence Carin
A new generative adversarial network is developed for joint distribution matching. Distinct from most existing approaches, that only learn conditional distributions, the proposed model aims to learn a joint distribution of multiple random variables (domains). This is achieved by learning to sample from conditional distributions between the domains, while simultaneously learning to sample from the marginals of each individual domain. The proposed framework consists of multiple generators and a single softmax-based critic, all jointly trained via adversarial learning. From a simple noise source, the proposed framework allows synthesis of draws from the marginals, conditional draws given observations from a subset of random variables, or complete draws from the full joint distribution. Most examples considered are for joint analysis of two domains, with examples for three domains also presented.
Peixian Liang, Jianxu Chen, Hao Zheng, Lin Yang, Yizhe Zhang, Danny Z. Chen
The Encoder-Decoder architecture is a main stream deep learning model for biomedical image segmentation. The encoder fully compresses the input and generates encoded features, and the decoder then produces dense predictions using encoded features. However, decoders are still under-explored in such architectures. In this paper, we comprehensively study the state-of-the-art Encoder-Decoder architectures, and propose a new universal decoder, called cascade decoder, to improve semantic segmentation accuracy. Our cascade decoder can be embedded into existing networks and trained altogether in an end-to-end fashion. The cascade decoder structure aims to conduct more effective decoding of hierarchically encoded features and is more compatible with common encoders than the known decoders. We replace the decoders of state-of-the-art models with our cascade decoder for several challenging biomedical image segmentation tasks, and the considerable improvements achieved demonstrate the efficacy of our new decoding method.
Shikib Mehri, Jinho Choi, Luis Fernando D'Haro, Jan Deriu, Maxine Eskenazi, Milica Gasic, Kallirroi Georgila, Dilek Hakkani-Tur, Zekang Li, Verena Rieser, Samira Shaikh, David Traum, Yi-Ting Yeh, Zhou Yu, Yizhe Zhang, Chen Zhang
This is a report on the NSF Future Directions Workshop on Automatic Evaluation of Dialog. The workshop explored the current state of the art along with its limitations and suggested promising directions for future work in this important and very rapidly changing area of research.