The CALMA system: an artificial neural network method for detecting masses and microcalcifications in digitized mammograms

Abstract The Computer Assisted Library for MAmmography (CALMA) project is a 5 years plan developed in a physics research frame in collaboration between Istituto Nazionale di Fisica Nucleare and many Italian hospitals. At present a large database of digitized mammographic images (more than 6000) was collected and a software based on neural network algorithms for the search of suspicious breast lesions was developed. Two tools are available: a microcalcification clusters hunter, based on supervised and unsupervised feedforward neural network, and a massive lesion searcher, based on a hibrid approach. Both the algorithms analyzed preprocessed digitized images by high-frequency filters. Clinical tests were performed to evaluate sensitivity and specificity of the system, considering the system as alone and as second reader. Results show that the system is ready to be implemented by medical industry. The CALMA project, just ended, has its natural development in the Grid Platform for CALMA project, where distributed users join common resources (images, tools, and statistical analysis).