/ AbstractThe CYGNO experiment employs an optical-readout Time Projection Chamber (TPC) to search for rare low-energy interactions using finely resolved scintillation images. While the optical readout provides rich topological information, it produces large, sparse megapixel images that challenge real-time triggering, data reduction, and background discrimination. We summarize two complementary machine-learning approaches developed within CYGNO. First, we present a fast and fully unsupervised strategy for online data reduction based on reconstruction-based anomaly detection. A convolutional autoencoder trained exclusively on pedestal images (i.e. frames acquired with GEM amplification disabled) learns the detector noise morphology and highlights particle-induced structures through localized reconstruction residuals, from which compact Regions of Interest (ROIs) are extracted. On real prototype data, the selected configuration retains (93.0 +/- 0.2)% of reconstructed signal intensity while discarding (97.8 +/- 0.1)% of the image area, with ~25 ms per-frame inference time on a consumer GPU. Second, we report a weakly supervised application of the Classification Without Labels (CWoLa) framework to data acquired with an Americium--Beryllium neutron source. Using only mixed AmBe and standard datasets (no event-level labels), a convolutional classifier learns to identify nuclear-recoil-like topologies. The achieved performance approaches the theoretical limit imposed by the mixture composition and isolates a high-score population with compact, approximately circular morphologies consistent with nuclear recoils.