/ AbstractJADES Data Release 5 (DR5) photometric catalogs and describes the methodologies used for source detection, deblending, photometry, uncertainty estimation, and catalog curation. The catalogs are constructed from 35 space-based imaging mosaics obtained with JWST/NIRCam, JWST/MIRI, HST/ACS, and HST/WFC3, combining approximately 1250 hours of JADES imaging with extensive additional public JWST and HST observations in the GOODS fields. Sources are identified using custom signal-to-noise-based detection and deblending algorithms optimized for the depth, resolution, and complex point-spread-function structure of JWST imaging. Source centroids, shapes, and photometric apertures are determined using a new fast two-dimensional Gaussian regression method applied to detection-image profiles. We provide forced circular-aperture photometry, ellipsoidal Kron photometry, and curve-of-growth measurements for every source in every band. We introduce a new pixel-level regression framework to model photometric uncertainties as a function of aperture size and local mosaic properties, accounting for correlated noise in heterogeneous JWST mosaics. Photometric redshifts are computed using template-based fitting applied to both small-aperture photometry on unconvolved images and Kron photometry on common-PSF mosaics. The JADES DR5 catalogs supersede previous JADES photometric releases, and are publicly released through the Mikulski Archive for Space Telescopes and an interactive web interface.