/ AbstractOn May 24th, 2023, the Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO), joined by the Advanced Virgo and KAGRA detectors, began the fourth observing run for a two-year-long dedicated search for gravitational waves. The LIGO Hanford and Livingston detectors have achieved an unprecedented sensitivity to gravitational waves, with an angle-averaged median range to binary neutron star mergers of 152 Mpc and 160 Mpc, and duty cycles of 65.0% and 71.2%, respectively, with a coincident duty cycle of 52.6%. The maximum range achieved by the LIGO Hanford detector is 165 Mpc and the LIGO Livingston detector 177 Mpc, both achieved during the second part of the fourth observing run. For the fourth run, the quantum-limited sensitivity of the detectors was increased significantly due to the higher intracavity power from laser system upgrades and replacement of core optics, and from the addition of a 300 m filter cavity to provide the squeezed light with a frequency-dependent squeezing angle, part of the A+ upgrade program. Altogether, the A+ upgrades led to reduced detector-wide losses for the squeezed vacuum states of light which, alongside the filter cavity, enabled broadband quantum noise reduction of up to 5.2 dB at the Hanford observatory and 6.1 dB at the Livingston observatory. Improvements to sensors and actuators as well as significant controls commissioning increased low frequency sensitivity. This paper details these instrumental upgrades, analyzes the noise sources that limit detector sensitivity, and describes the commissioning challenges of the fourth observing run.