/ AbstractIn state-of-the-art Positron Emission Tomography (PET), information about annihilation photon polarization is unavailable. Here, we present a PET scanner built from plastic scintillators, where annihilation photons primarily interact via the Compton effect, providing information about both photon polarization and propagation direction. Using this plastic-based PET, we determined the distribution of the relative angle between polarization planes of photons from positron-electron annihilation in a porous polymer. The amplitude of the observed distribution is smaller than predicted for maximally quantum-entangled two-photon states but larger than expected for separable photons. This result can be well explained by assuming that photons from pick-off annihilation are not entangled, while photons from direct and para-positronium annihilations are maximally entangled. Our result indicates that the degree of entanglement depends on the annihilation mechanism in matter, opening new avenues for exploring polarization correlations in PET as a diagnostic indicator.