Multi-axis fields boost SABRE hyperpolarization

Significance Magnetic resonance techniques are often limited by intrinsically low signals. Hyperpolarization methods such as signal amplification By reversible exchange (SABRE) circumvent these limitations by artificially generating higher nuclear spin polarizations. Here, we show that the SABRE signal may be boosted up to 10 times over conventional SABRE methods using shaped multiaxis magnetic fields generated by a computer-aided pulse sequence design algorithm and explain the strategy the algorithm found, which differs from previous approaches.