/ AbstractFor the first time the scientific community in Latin America working at the forefront of research in high energy, cosmology and astroparticle physics (HECAP) have come together to discuss and provide scientific input towards the development of a regional strategy. The present document, the Latin American HECAP Physics Briefing Book, is the result of this ambitious bottom-up effort. This report contains the work performed by the Preparatory Group to synthesize the main contributions and discussions for each of the topical working groups. This briefing book discusses the relevant emerging projects developing in the region and considers potentially impactful future initiatives and participation of the Latin American HECAP community in international flagship projects to provide the essential input for the creation of a long-term HECAP strategy in the region.