/ AbstractThe Lunar Laser Ranging (LLR) experiment has accumulated 50 years of range data of improving accuracy from ground stations to the laser retroreflector arrays (LRAs) on the lunar surface. The upcoming decade offers several opportunities to break new ground in data precision through the deployment of the next generation of single corner-cube lunar retroreflectors and active laser transponders. This is likely to expand the LLR station network. Lunar dynamical models and analysis tools have the potential to improve and fully exploit the long temporal baseline and precision allowed by millimetric LLR data. Some of the model limitations are outlined for future efforts. Differential observation techniques will help mitigate some of the primary limiting factors and reach unprecedented accuracy. Such observations and techniques may enable the detection of several subtle signatures required to understand the dynamics of the Earth-Moon system and the deep lunar interior. LLR model improvements would impact multi-disciplinary fields that include lunar and planetary science, Earth science, fundamental physics, celestial mechanics and ephemerides.