Development of Hyperthermia Measurable Fiber Radiometric Thermometer for Monitoring Tissue Temperature during Thermo-therapy

ABSTRACT: Temperature monitoring is extremely im-portant during thermotherapy. Fiber-optic temperature sensors are preferred because of their flexibility and im-munity to electromagnetic interference. Although many types of fiber-optic sensors have been developed, it re-mains challenging for clinically adopting them. Here, we report a silica fiber-based radiometric thermometer using a low-cost extended InGaAs detector to detect black body radiation between 1.7um to 2.4 um. For the first time, this silica fiber-based thermometer is capable of measuring temperature down to 35°C, making it suitable for seamless integration with current silica fiber catheters used in laser interstitial thermotherapy to monitor hyperthermia during a surgery. The feasibility, capability, and sensitivity of track-ing tissue temperature variation were proved through ex vivo and in vivo tissue studies. The technology is promising for being translated into clinics after further improving the signal to noise ratio.